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Symptoms of vitamin C deficiency, such as poor wound healing and lethargy, result from impairment of these enzymatic reactions and insufficient collagen, carnitine, and catecholamine synthesis (see Deficiency). The distribution of ascorbic acid between various cellular components of blood, in normal individuals, and its relation to the plasma concentration.

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The European Investigation into Cancer and Nutrition (EPIC)-Norfolk prospective cohort study investigated the relationship between vitamin C status and incident heart failure in healthy adults (9,187 men and 11,112 women, aged 58.1±9.2 years) (21). Coronary heart disease (CHD) is characterized by the build-up of plaque inside the arteries that supply blood to the heart (atherosclerosis). Over years of build-up and accumulated damage to the coronary arteries, CHD may culminate in a myocardial infarction or heart attack. Once plasma ascorbic acid levels reach saturation, additional vitamin C is largely excreted in the urine. Ascorbic Acid: Biochemistry and Biomedical Cell Biology. Vitamin C for the treatment of recurrent furunculosis in patients with imparied neutrophil functions. Notably, intravenous administration of vitamin C bypasses absorptive control in the intestine such that very high concentrations of ascorbic acid can be achieved in the plasma; over time, renal excretion restores vitamin C to baseline plasma levels (9) (see Cancer Treatment).

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